| 洛美沙星透皮吸收搽剂在猪体内的药物动力学特征 |
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| 引用本文： | 黄一帆,俞道进,姚金水. 洛美沙星透皮吸收搽剂在猪体内的药物动力学特征[J]. 福建农林大学学报(自然科学版), 2003, 32(2): 217-220 |
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| 作者姓名： | 黄一帆 俞道进 姚金水 |
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| 作者单位： | 福建农林大学动物科学学院,福建,福州,350002 |
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| 基金项目： | 福建省自然科学基金资助项目(B0210023). |
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| 摘 要： | 洛美沙星搽剂以单剂量4mg·kg-1涂搽给药,给药后间隔一定时间采血,用高效液相色谱法(HPLC)测定血药质量)为(2.225±0.212)h,峰值出现时间(Tp)为(6.253±浓度,并分析代谢动力学特征.其主要动力学参数吸收半衰期(T1/2Ka)为(8.191±0.993)h,血药质量浓度峰值(Cmax)为(1.032±0.116)mg·L-1,有效质量浓度维持0.411)h,消除半衰期(T1/2Ke时间[Tcp(ther)]为(30.671±3.484)h,表观分布容积(Vd)为(2.392±0.246)L·kg-1.
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| 关 键 词： | 洛美沙星搽剂 药物动力学 高效液相色谱法 猪 |
| 文章编号： | 1006-7817(2003)02-0217-04 |
| 修稿时间： | 2002-10-28 |
Pharmacokinetics of the lomefloxacin liniment of transdermal absorbent preparation in pigs |
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| Abstract: | A single dose (4 mg·kg-1) of lomefloxacin liniment was applied to the skins of healthy pigs. The blood samples were collected at different time intervals. Plasma concentration of lomefloxacin and its metabolite were determined by a high performance liquid chromatography (HPLC). The main pharmacokinetic parameters were as follows: half life time of absorption (T1/2Ka) (2.225±0.212) h, appearance time of maximum (Tp) (6.253±0.411) h, half life time of elimination (T1/2Ke) (8.191±0.993) h , maximum of plasma concentration (Cmax) (1.032±0.116) mg·L-1, duration of therapeutic plasma level [Tcp(ther)] (30.671±3.484) h, apparent volume of distribution (Vd) (2.392±0.246) L·kg-1. |
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| Keywords: | lomefloxacin linement pharmacokinetics high performance liquid chromatography pig |
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