Production of delayed ataxia by carbamate acid esters

Thirty-eight carbamates and thiocarbamates were evaluated for the production of delayed neurotoxicity in the mature White Leghorn hen. Several thiocarbamates including phenyl-N-ethylthiocarbamate and s-2,3-dichloroallyl diisopropylthiocarbamate (diallate) produced symptoms of severe delayed neurotoxicity following repeated oral administration. The results of these experiments do not preclude the possibility that neurotoxic carbamates and organophosphorous compounds may share a common site of action.