Four New Chloro-Eremophilane Sesquiterpenes from an Antarctic Deep-Sea Derived Fungus,Penicillium sp. PR19N-1 |
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| Authors: | Guangwei Wu Aiqun Lin Qianqun Gu Tianjiao Zhu Dehai Li |
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| Affiliation: | Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; E-Mails: (G.W.); (A.L.); (Q.G.) |
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| Abstract: | ![]()
A new chloro-trinoreremophilane sesquiterpene 1, three new chlorinated eremophilane sesquiterpenes 2–4, together with a known compound, eremofortine C (5), were isolated from an Antarctic deep-sea derived fungus, Penicillium sp. PR19N-1. Structures were established using IR, HRMS, 1D and 2D NMR techniques. In addition, the plausible metabolic network of these isolated products is proposed. Compound 1 showed moderate cytotoxic activity against HL-60 and A549 cancer cell lines. |
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| Keywords: | chlorinated eremophilane sesquiterpene Antarctic deep-sea derived fungus Penicillium sp. |
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