Bioactive Polyoxygenated Steroids from the South China Sea Soft Coral,Sarcophyton sp |
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| Authors: | Zenglei Wang Hua Tang Pan Wang Wei Gong Mei Xue Hongwei Zhang Taofang Liu Baoshu Liu Yanghua Yi Wen Zhang |
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| Institution: | Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China; E-Mails: (Z.W.); (H.T.); (P.W.); (W.G.); (M.X.); (H.Z.); (T.L.); (B.L.) |
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| Abstract: | Seven new polyoxygenated steroids (1–7) were isolated together with seven known analogues (8–14) from the South China Sea soft coral, Sarcophyton sp. The structures of the new compounds were identified on the basis of extensive spectroscopic analysis and comparison with reported data. All the steroids are characterized with 3β,5α,6β-hydroxy moiety, displaying carbon skeletons of cholestane, ergostane, gorgostane and 23,24-dimethyl cholestane. In the in vitro bioassay, metabolites exhibited different levels of antimicrobial activity against bacterial species Escherichia coli and Bacillus megaterium, and fungal species Microbotryum violaceum and Septoria tritici. No inhibition was detected towards microalga Chlorella fusca. Preliminary structure-activity analysis suggests that the 11α-acetoxy group may increase both antibacterial and antifungal activities. The terminal-double bond and the cyclopropane moiety at the side chain may also contribute to the bioactivity. |
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| Keywords: | Sarcophyton sp steroid bioactivity antibacterial antifungal |
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