Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells |
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| Authors: | Zhang Z Schuler T Zupancic M Wietgrefe S Staskus K A Reimann K A Reinhart T A Rogan M Cavert W Miller C J Veazey R S Notermans D Little S Danner S A Richman D D Havlir D Wong J Jordan H L Schacker T W Racz P Tenner-Racz K Letvin N L Wolinsky S Haase A T |
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| Institution: | Department of Microbiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. |
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| Abstract: | In sexual transmission of simian immunodeficiency virus, and early and later stages of human immunodeficiency virus-type 1 (HIV-1) infection, both viruses were found to replicate predominantly in CD4(+) T cells at the portal of entry and in lymphoid tissues. Infection was propagated not only in activated and proliferating T cells but also, surprisingly, in resting T cells. The infected proliferating cells correspond to the short-lived population that produces the bulk of HIV-1. Most of the HIV-1-infected resting T cells persisted after antiretroviral therapy. Latently and chronically infected cells that may be derived from this population pose challenges to eradicating infection and developing an effective vaccine. |
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