Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists |
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| Authors: | T Honoré S N Davies J Drejer E J Fletcher P Jacobsen D Lodge F E Nielsen |
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| Institution: | Ferroson Research Division, Soeborg, Denmark. |
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| Abstract: | The N-methyl-D-aspartate (NMDA)-subtype of glutamate receptors has been well described as a result of the early appearance of NMDA antagonists, but no potent antagonist for the "non-NMDA" glutamate receptors has been available. Quinoxalinediones have now been found to be potent and competitive antagonists at non-NMDA glutamate receptors. These compounds will be useful in the determination of the structure-activity relations of quisqualate and kainate receptors and the role of such receptors in synaptic transmission in the mammalian brain. |
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