Butremycin,the 3-Hydroxyl Derivative of Ikarugamycin and a Protonated Aromatic Tautomer of 5′-Methylthioinosine from a Ghanaian Micromonospora sp. K310 |
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| Authors: | Kwaku Kyeremeh Kojo Sekyi Acquah Anil Sazak Wael Houssen Jioji Tabudravu Hai Deng Marcel Jaspars |
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| Institution: | 1.Marine and Plant Laboratory of Ghana, Department of Chemistry, University of Ghana, Accra, P.O. Box LG 56, Ghana; E-Mail: ;2.Department of Biology, Faculty of Art and Science, Ondokuz Mayis University, Kurupelit Samsun 55139, Turkey; E-Mail: ;3.Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Old Aberdeen AB24 3UE, Scotland, UK; E-Mails: (W.H.); (J.T.); (H.D.);4.Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK |
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| Abstract: | A new actinomycete strain Micromonospora sp. K310 was isolated from Ghanaian mangrove river sediment. Spectroscopy-guided fractionation led to the isolation of two new compounds from the fermentation culture. One of the compounds is butremycin (2) which is the (3-hydroxyl) derivative of the known Streptomyces metabolite ikarugamycin (1) and the other compound is a protonated aromatic tautomer of 5′-methylthioinosine (MTI) (3). Both new compounds were characterized by 1D, 2D NMR and MS data. Butremycin (2) displayed weak antibacterial activity against Gram-positive S. aureus ATCC 25923, the Gram-negative E. coli ATCC 25922 and a panel of clinical isolates of methicillin-resistant S. aureus (MRSA) strains while 3 did not show any antibacterial activity against these microbes. |
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| Keywords: | Micromonospora macrolactam tautomer tetramic acid mangroves |
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