Solwaric Acids A and B,Antibacterial Aromatic Acids from a Marine Solwaraspora sp. |
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| Authors: | Gregory A Ellis Thomas P Wyche Charles G Fry Doug R Braun Tim S Bugni |
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| Institution: | 1.Pharmaceutical Sciences Division, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705, USA; E-Mails: (G.A.E.); (T.P.W.); (D.R.B.);2.Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706, USA; E-Mail: |
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| Abstract: | Two novel trialkyl-substituted aromatic acids, solwaric acids A and B, were isolated from a marine Solwaraspora sp. cultivated from the ascidian Trididemnum orbiculatum. Solwaric acids A and B were isotopically labeled with U-13C glucose, and analysis of a 13C–13C COSY allowed for unambiguous determination of the location of the phenyl methyl group. The two novel compounds demonstrated antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA). |
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| Keywords: | Trididemnum orbiculatum Solwaraspora methicillin-resistant Staphylococcus aureus |
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