可食用植物疫苗的探讨

利用植物生物反应器生产口服疫苗已成为目前研究的热点。与传统疫苗相比,植物源性疫苗具有安全、稳定、高效和廉价等优点。植物作为生产疫苗的载体可将抗原表达于植物的可食部位。当植物被食用或饲喂时,植物源性疫苗可激发保护性的黏膜免疫应答。综述了植物源性口服疫苗的原理,并对可能出现的问题及解决途径进行了探讨。

Study on Edible Plant Vaccine

Much attention has been focused on the plant-derived oral vaccine production. Compared with the traditional vaccines,the plant-derived oral vaccine are safe,stable,efficient and cheap etc. Plant as the delivery vehicle for vaccine can express antigen in edible parts such as seeds and tubers. The plant-derived vaccine can induce protective mucosal immune responses when the transgenic plants are provided as food or feed. This paper reviewed the theory of plant-derived oral vaccine and discussed some problems that need to be resolved.