| 转基因猪研究新进展 |
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| 引用本文： | 孙武,娜日苏.转基因猪研究新进展[J].安徽农业科学,2014(15):4650-4652,4655. |
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| 作者姓名： | 孙武 娜日苏 |
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| 作者单位： | 西南大学动物科技学院;重庆市牧草与草食家畜重点实验室/重庆市草食动物资源保护与利用工程技术研究中心; |
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| 基金项目： | 中央高校基本科研业务费专项(XDJK2010C101);西南大学博士基金项目(SWU111048);国家自然科学基金面上项目(31172195) |
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| 摘 要： | 由于猪既是重要的经济动物,又是常用的实验动物,并且因为其解剖、组织、生理和营养代谢等方面与人类相似,因此转基因猪的研究意义重大。纵观转基因猪的发展历史,关键核心技术包括显微注射技术、体细胞核移植技术、精子载体技术、胚胎干细胞介导技术、病毒转染技术、基因打靶、ZFN技术和TALENS技术。科学家们通过这些技术对猪进行了大量研究,已经在生命科学领域取得了令人欣慰的成就。
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| 关 键 词： | 转基因猪 基因打靶 锌指核酸酶 RNA干扰 转录激活因子效应物核酸酶 |
Research Progress in Transgenic Pigs |
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| SUN Wu,NA Ri-su.Research Progress in Transgenic Pigs[J].Journal of Anhui Agricultural Sciences,2014(15):4650-4652,4655. |
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| Authors: | SUN Wu NA Ri-su |
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| Institution: | (Cbongqing Key Laboratory of Forage and Herbivore/Chongqing Engineering Research Center for Herbivores Re- source Protection and Utilization, College of Animal Science and Technology of Southwest University, Chongqing 400716) |
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| Abstract: | Porcine is an important economic animals in livestock,and is commonly used as experimental animals model. The characteristic of pigs in anatomy,tissue physiology and nutrition metabolism is similar with human,therefore,the research about transgenic pigs is significant. Throughout the history of gene transfer in pigs,the key core technologies include： microinjection,somatic cell nuclear transfer,sperm vector, embryonic stem cell-mediated,viral transfection,gene targeting,ZFN technology,TALENS technology. By studying these techniques scientists have done has made a lot gratifying achievements in pigs,in life sciences today. |
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| Keywords: | Transgenic pigs Gene targeting ZFN RNAi TALENS |
| 本文献已被 CNKI 维普 等数据库收录！ |
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