| 左卡尼汀对家兔抗氧化作用的研究 |
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| 引用本文： | 许勇,李娜,王桂华,杨茗,栾海云.左卡尼汀对家兔抗氧化作用的研究[J].安徽农业科学,2013(17):7568-7569. |
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| 作者姓名： | 许勇 李娜 王桂华 杨茗 栾海云 |
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| 作者单位： | 滨州医学院药学院,药物研究所,山东烟台264003;滨州医学院基础学院,山东烟台,264003 |
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| 基金项目： | 山东省烟台市科技发展计划项目 |
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| 摘 要： | 目的]研究左卡尼汀口服液(LC)在家兔体内的抗氧化作用,探讨其对兔血浆、脑组织及脑脊液中SOD、GSH-PX、CAT、T-AOC和MDA活力的影响。方法]健康成熟的新西兰大耳兔,以1 ml/kg的剂量单次灌胃给入左卡尼汀,于药前和药后不同时间测定血浆、脑组织和脑脊液中SOD、GSH-PX、CAT、T-AOC和MDA活力。结果]给药后血液、脑组织及脑脊液SOD、GSH-PX、CAT、T-AOC活性较给药前显著升高(P0.05);而MDA含量较给药前显著降低(P0.05)。结论]左卡尼汀口服液在家兔体内具有抗氧化作用。
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| 关 键 词： | 左卡尼汀 抗氧化 家兔 |
Study of Antioxidant Effects of L-carnitine on Rabbit |
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| Institution: | XU Yong;Binzhou Medical University; |
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| Abstract: | Abstract Objective ] To study antioxidant effects of LC, and investigate the effect of LC on SOD, GSH-PX, CAT, T-AOC and MDA in the blood, brain tissue and CSF of rabbit. Method] A single dose of 1 ml/kg LC was taken orally to New Zealand rabbits with big ears. The plas- ma, brain tissue and CSF samples were taken and measured before and after administration respectively. Resuh ] After LC administration, SOD, GSH-PX CAT, and T-AOC activity in blood, brain tissue and cerebrospinal fluid significantly increased （P 〈0.05）, while MDA signifi- cantly decreased （P 〈 0. 05）. Conclusion ] LC shows antioxidant effects in rabbit, |
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| Keywords: | L-carnitine Antioxidant Rabbit |
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