The development of multiple cutaneous inverted papilloma following ovariohysterectomy in a dog |
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| Authors: | JS Munday AF French AR MacNamara |
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| Affiliation: | 1. Department of Pathobiology, Institute of Veterinary, Animal and Biomedical Sciences , Massey University , Private Bag 11222, Palmerston North, 4442, New Zealand E-mail: j.munday@massey.ac.nz;2. New Zealand Veterinary Pathology Ltd , Palmerston North, New Zealand;3. Levin &4. Horowhenua Veterinary Centre , Levin, New Zealand |
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| Abstract: | Abstract CASE HISTORY: Ovariohysterectomy was performed on an adult Cavalier King Charles Spaniel. The skin that had been clipped for surgery was noticed to be erythematous 8 days later. CLINICAL AND PATHOLOGICAL FINDINGS: Poorly defined patches containing multiple papules were visible bilaterally within the clipped skin. These became larger over the following 2 weeks, and samples were collected for histology. Seven days later, the lesions were multiple raised masses, up to 5 cm in diameter. Histology revealed numerous cup-shaped epidermal proliferations extending into the dermis. The presence of keratinocytes with increased quantities of blue-grey cytoplasm, and koilocytosis suggested papillomavirul infection; Canis familiaris papillomavirus (CfPV-2) DNA was amplified from two separate samples. Complete regression was observed 8 weeks after the lesions had been initially observed. DIAGNOSIS: Multiple inverted papilloma confined to skin that had been clipped for surgery. CLINICAL RELEVANCE: This is the first time that the development of canine cutaneous papillomas has been associated with surgery. The nature of the association between surgery and development of the papillomas is uncertain. However, it is possible that damage to superficial skin could promote the formation of papillomas. This is the first identification of CfPV-2 in New Zealand. |
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| Keywords: | Inverted papilloma papillomavirus surgery skin New Zealand dog |
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