| 基因盒-整合子系统介导的细菌多重耐药性 |
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| 引用本文： | 丁良君,张秀英,付锐,崔晓文.基因盒-整合子系统介导的细菌多重耐药性[J].中国兽药杂志,2006,40(3):32-35. |
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| 作者姓名： | 丁良君 张秀英 付锐 崔晓文 |
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| 作者单位： | 1. 东北农业大学动物医学院,黑龙江,哈尔滨,150030
2. 伊春市金山屯区林业医院,黑龙江伊春,150026 |
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| 摘 要： | 细菌多重耐药性的传播和扩散变得越来越严重，给临床治疗带来诸多困难，使得抗菌药物在兽医临床上的应用引起很大的争议。细菌可通过多种方式逃避抗菌药物的治疗，最主要的是从外源获得耐药基因，基因盒-整合子系统是近年来的研究热点，细菌通过整合子系统捕获外来的耐药基因，并在位于整合子上游的启动子的作用下得到表达，使细菌具有耐药及多重耐药性。本文主要对基因盒-整合子系统的耐药机制进行探讨。
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| 关 键 词： | 整合子 基因盒 多重耐药 |
| 文章编号： | 1002-1280（2006）03-0032-04 |
| 收稿时间： | 2005-10-24 |
| 修稿时间： | 2005年10月24 |
Multidrug Resistance in Bacteria Mediated by Integrons and Gene Cassettes |
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| DING Liang-jun,ZHANG Xiu-ying,FU Rui,CUI Xiao-wen.Multidrug Resistance in Bacteria Mediated by Integrons and Gene Cassettes[J].Chinese Journal of Veterinary Drug,2006,40(3):32-35. |
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| Authors: | DING Liang-jun ZHANG Xiu-ying FU Rui CUI Xiao-wen |
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| Institution: | 1. College of Veterinary Medicine, Noah-east Agricultural University, Harbin, Heilongjiang 150030 ; 2. Forestry Hospital of Jin Shan Tun of Yi Chun, Yichun, Heilongjiang 150026 ; China |
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| Abstract: | The development and spread of muhidrug resistant of bacteria become more and more serious, and the use of antimicrobial agents in veterinary services is widely debated. Bacteria can catch adventive drug resistant gene by integrons and gene cassettes system , and express it through the promoter which locates in the upper stream of integrons. It was the main causion of the multidrug resistant of bacteria. This article mainly approach the mechanism of integrons and gene cassettes mediating multidrug resistant of bacteria. |
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| Keywords: | integrons gene cassettes multidrug resistant |
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