In vitro suppression of quercetin on hypertrophy and extracellular matrix accumulation in rat glomerular mesangial cells cultured by high glucose期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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In vitro suppression of quercetin on hypertrophy and extracellular matrix accumulation in rat glomerular mesangial cells cultured by high glucose

Authors:	Tang Dao-quan Wei Ya-qin Yin Xiao-xing Lu Qian Hao Hui-hui Zhai Yun-peng Wang Jian-yun Ren Jin

Institution:	^a Department of Pharmaceutical Analysis, School of Pharmacy, Xuzhou Medical College, Xuzhou 221004, China ^b Key Laboratory of New Drug and Clinical Application, Xuzhou Medical College, Xuzhou 221004, China ^c Department of Clinical Pharmacology, School of Pharmacy, Xuzhou Medical College, Xuzhou 221004, China

Abstract:	Quercetin's protective effects on the glomerulosclerosis of diabetic nephropathy (DN) in rat mesangial cells were investigated. The cell cycles, type IV collagen and laminin, TGF-β₁ mRNA, Smad 2/3 and Smad 7, and activities of cell antioxidases were measured. Compared with the high glucose group, quercetin may decrease the cell percentages of G₀/G₁ phase, Smad 2/3 expression, laminin and type IV collagen, and TGF-β₁ mRNA level significantly. The antioxidant capacity, the cell percentages of S phase and Smad 7 expression was significantly increased by quercetin. These results suggest that quercetin is a protective agent against glomerulosclerosis in DN.

Keywords:	Quercetin TGF-β₁ Smads Cell cycles Laminin and type IV collagen Oxidative stress
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