Neuroprotective bakkenolides from the roots of Valeriana jatamansi |
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| Authors: | Xu Jing Yang Bo Guo Yuanqiang Jin Da-qing Guo Ping Liu Cuizhou Hou Wenbin Zhang Tiejun Gui Liping Sun Zhanping |
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| Institution: | a College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, Chinab College of Pharmacy, Harbin University of Commerce, Harbin 150076, Chinac School of Medicine, Nankai University, Tianjin 300071, Chinad Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China |
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| Abstract: | Two new bakkenolides, valerilactones A (1), and B (2), and two known analogues, bakkenolide-H (3) and bakkenolide-B (4), were isolated from the roots of Valeriana jatamansi. Their structures and relative configurations were elucidated by spectroscopic methods (IR, ESIMS, HRESIMS, 1D and 2D NMR) and by comparison of their NMR data with those of related compounds. Compounds 1, 2, and 3 exhibited potent neuroprotective effects against MPP+-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells. |
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| Keywords: | Valeriana jatamansi Bakkenolide Neuroprotective effect MPP+ Sesquiterpene |
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