| 炔雌醇对大鼠睾丸的毒性与氧化损伤作用 |
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| 引用本文： | 杨翠军,崔文典,刘芳,马媛媛,高翠,葛剑.炔雌醇对大鼠睾丸的毒性与氧化损伤作用[J].河南农业科学,2012,41(11):150-152. |
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| 作者姓名： | 杨翠军 崔文典 刘芳 马媛媛 高翠 葛剑 |
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| 作者单位： | 1. 河北北方学院,河北张家口,075000
2. 张家口市草原监理站,河北张家口,075000 |
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| 基金项目： | 河北北方学院自然科学基金项目 |
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| 摘 要： | 为了研究环境雌激素炔雌醇的生殖毒性与活性氧的关系,按0.1、0.5、1.0、5.0mg/kg的药物剂量对雄性大鼠给药,测定大鼠的睾丸质量、睾丸及血浆中超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)含量。结果表明:随着给药剂量增加,睾丸质量显著下降,睾丸萎缩;睾丸组织和血浆中SOD和GSH-Px水平显著下降。说明炔雌醇的生殖毒性与细胞活性氧(ROS)有关,炔雌醇可能通过降低抗氧化酶的含量,增加ROS的含量,导致生殖损伤。
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| 关 键 词： | 炔雌醇 大鼠 睾丸 活性氧 超氧化物歧化酶 谷胱甘肽过氧化物酶 |
The Relationship between Reproductive Toxicity and Oxidative Damage Induced by Ethinylestradiol in Rats |
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| YANG Cui-jun
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CUI Wen-dian
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LIU Fang
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MA Yuan-yuan
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GAO Cui
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GE Jian.The Relationship between Reproductive Toxicity and Oxidative Damage Induced by Ethinylestradiol in Rats[J].Journal of Henan Agricultural Sciences,2012,41(11):150-152. |
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| Authors: | YANG Cui-jun CUI Wen-dian LIU Fang MA Yuan-yuan GAO Cui GE Jian |
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| Institution: | 1(1.Hebei North University,Zhangjiakou 075000,China; 2.Zhangjiakou Grassland Management Station,Zhangjiakou 075000,China) |
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| Abstract: | To explore the relationship between reproductive toxicity and oxidative damage induced by ethinylestradiol,the rats were treated with different dosages of ethinylestradiol,which were 0.1,0.5,1.0,5.0 mg/kg,respectively.The testicular weight and the contents of SOD and GSH-Px in plasma and testicular were measured.The results showed that testicular weight decreased significantly with increasing dosages of ethinylestradiol.The antioxidant enzymes including SOD and GSH-Px in testicular tissue and plasma all decreased significantly.In a conclusion,there is a close relationship between reproductive toxicity of ethinylestradiol and ROS. |
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| Keywords: | ethinylestradiol rat testicular ROS SOD GSH-Px |
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