| 阳起石、菟丝子与淫羊藿对肾阳虚大鼠性激素及其受体表达的影响 |
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| 引用本文： | 喻琴,王东升,张世栋,董书伟,武小虎,桑梦琪,邵丹,严作廷.阳起石、菟丝子与淫羊藿对肾阳虚大鼠性激素及其受体表达的影响[J].中国兽医学报,2019(3):535-540. |
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| 作者姓名： | 喻琴 王东升 张世栋 董书伟 武小虎 桑梦琪 邵丹 严作廷 |
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| 作者单位： | 1.中国农业科学院兰州畜牧与兽药研究所农业部兽用药物创制重点实验室/甘肃省中兽药工程技术研究中心;2.甘肃农业大学 |
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| 基金项目： | "十三五"国家重点研发基金资助项目(2017YFD0502201);中国农业科学院科技创新工程基金资助项目(CAAS-ASTIP-2014-LIHPS-03) |
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| 摘 要： | 为了比较阳起石、菟丝子、淫羊藿对肾阳虚模型大鼠的治疗效果,通过肌肉注射氢化可地松制作了肾阳虚大鼠模型,并在3种药物治疗前后分别对体质量、脏器指数、子宫角长度、子宫中段外径、激素水平及其受体基因的表达情况进行了比较研究。结果显示,阳起石、菟丝子、淫羊藿均能够显著增加大鼠的肝脏指数,提高大鼠黄体生成素、卵泡刺激素、雌激素及激素受体的表达水平,其中阳起石与菟丝子对激素分泌的调节优于淫羊藿,而阳起石与淫羊藿对激素受体表达的调节优于菟丝子。结果表明,这3种药物能通过促进激素分泌和激素受体的表达来改善肾阳虚动物子宫和卵巢的功能,且3种药物的疗效各有优势。
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| 关 键 词： | 阳起石 菟丝子 淫羊藿 肾阳虚 性激素 性激素受体 |
Effect of Actinolite,Cuscutae Semen and Epimedii Folium on levels of hormone and their receptors in kidney-yang deficiency rats |
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| YU Qin,WANG Dong-sheng,ZHANG Shi-dong,DONG Shu-wei,WU Xiao-hu,SANG Meng-qi,SHAO Dan,YAN Zuo-ting.Effect of Actinolite,Cuscutae Semen and Epimedii Folium on levels of hormone and their receptors in kidney-yang deficiency rats[J].Chinese Journal of Veterinary Science,2019(3):535-540. |
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| Authors: | YU Qin WANG Dong-sheng ZHANG Shi-dong DONG Shu-wei WU Xiao-hu SANG Meng-qi SHAO Dan YAN Zuo-ting |
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| Institution: | (Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture/Engineering and Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province ,Lanzhou Institute of Husbaridry and Pharmaceutical Sciences of CAAS , Lanzhou 730050, China;Gansu Agricultural University , Lanzhou 7300709 China) |
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| Abstract: | YU Qin;WANG Dong-sheng;ZHANG Shi-dong;DONG Shu-wei;WU Xiao-hu;SANG Meng-qi;SHAO Dan;YAN Zuo-ting(Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture/Engineering and Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province ,Lanzhou Institute of Husbaridry and Pharmaceutical Sciences of CAAS , Lanzhou 730050, China;Gansu Agricultural University , Lanzhou 7300709 China) |
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| Keywords: | Actinolite Cuscutae Semen Epimedii Folium kidney-yang deficiency sexual hormone sexual hormone receptor |
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