| H9N2亚型禽流感病毒血凝素基因的遗传变异 |
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| 引用本文： | 刘红旗,彭大新,程坚,贾立军,张如宽,刘秀梵. H9N2亚型禽流感病毒血凝素基因的遗传变异[J]. 扬州大学学报(农业与生命科学版), 2002, 23(2): 6-9 |
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| 作者姓名： | 刘红旗 彭大新 程坚 贾立军 张如宽 刘秀梵 |
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| 作者单位： | 扬州大学农业部畜禽传染病学重点开放实验室,江苏扬州,225009;扬州大学农业部畜禽传染病学重点开放实验室,江苏扬州,225009;扬州大学农业部畜禽传染病学重点开放实验室,江苏扬州,225009;扬州大学农业部畜禽传染病学重点开放实验室,江苏扬州,225009;扬州大学农业部畜禽传染病学重点开放实验室,江苏扬州,225009;扬州大学农业部畜禽传染病学重点开放实验室,江苏扬州,225009 |
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| 基金项目： | 国家高新技术发展计划项目(8632001AA213041),江苏省高校高新技术产业化项目(JH01067) |
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| 摘 要： | 连续3年对某鸡场禽流感感染鸡群进行跟踪监测,对使用疫苗前与使用疫苗后不同时段分离的H9N2亚型禽流感病毒的血凝素(HA)基因进行全序列分析,研究其H9N2亚型禽流感病毒在同亚型灭活疫苗的选择压力下的遗传变异。结果表明:在使用第1次分离的病毒株制备的疫苗后8个月分离该病毒株,其HA基因仅有1个氨基酸发生变异;继续使用该疫苗第2年分离的该病毒株,其HA基因有20个氨基酸发生变异。
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| 关 键 词： | 禽流感病毒 疫苗选择压力 遗传变异 |
| 文章编号： | 1671-4652(2002)02-0006-04 |
| 修稿时间： | 2001-12-26 |
GENETIC MUTATIONS OF THE HEMAGGLUTININ GENES OF H9N2 SUBTYPE AVIAN INFLUENZA VIRUSES |
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| Abstract: | In order to explore genetic mutations of hemagglutinin (HA) genes of H9N2 subtype avian influenza viruses (AIVs) under selective pressure of vaccination, infection in chicken flocks on a farm was monitored in three years and H9N2 subtype viruses were isolated either before or after vaccination procedure was introduced. Complete sequence analysis of HA genes of these isolates showed that HA gene of the isolate, which was isolated 8 months after vaccination by vaccine from the first isolate, had only one amino acid different from that of the vaccine strain. But greater changes were seen in the HA genes of the virus of the following second year after vaccination, with 20 amino acids different from that of the vaccine strain. |
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| Keywords: | avian influenza viruses selective pressure by vaccination genetic mutation |
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