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Effects of treatment with St. John's Wort on blood glucose levels and pain perceptions of streptozotocin-diabetic rats |
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| Authors: | Can Özgür Devrim Öztürk Yusuf Öztürk Nilgün Sagratini Gianni Ricciutelli Massimo Vittori Sauro Maggi Filippo |
| Institution: | a Department of Pharmacology, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey;b Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey;c School of Pharmacy, University of Camerino, 62032 Camerino, Italy |
| Abstract: | This present study was undertaken to examine treating effects of St. John's Wort (SJW) extract on nociceptive perception of STZ-diabetic animals based on its potential antidiabetic and antinociceptive activities. One week administrations of SJW extract (125 and 250 mg/kg) induced significant decrease in high blood glucose levels of three weeks STZ-diabetic rats and improved their dysregulated metabolic parameters. In addition, SJW extract treatment caused restoration in the mechanical hyperalgesia of diabetic animals. These findings provide a rationale for the traditional use of SJW against diabetes and display the potential of this plant as a new drug candidate/source for the treatment of diabetic pain. |
| Keywords: | St John's Wort Hypericum perforatum Diabetes mellitus Rutin Tail pinch Tail flick |
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