| 鼻咽癌细胞中CD147、E-cadherin的表达及其意义 |
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| 引用本文： | 刘丹,赵颖海,景志亮,罗爱华,姜汉国,李飞虹.鼻咽癌细胞中CD147、E-cadherin的表达及其意义[J].湛江医学院学报,2012,30(1):4-6,10. |
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| 作者姓名： | 刘丹 赵颖海 景志亮 罗爱华 姜汉国 李飞虹 |
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| 作者单位： | 刘丹 (广东医学院基础医学院病理学教研室,广东湛江,524023) ； 赵颖海 (广东医学院基础医学院病理学教研室,广东湛江,524023) ； 景志亮 (广东医学院附属医院病理科,广东湛江,524001) ； 罗爱华 (广东省高州市人民医院病理科,广东高州,525200) ； 姜汉国 (广东医学院基础医学院病理学教研室,广东湛江,524023) ； 李飞虹 (广东医学院基础医学院病理学教研室,广东湛江,524023) ； |
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| 基金项目： | 广东省湛江市第4批科技攻关项目 |
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| 摘 要： | 目的探讨鼻咽癌细胞中CD147、E-cadherin的表达及其意义。方法用免疫组化SP法检测55例鼻咽癌细胞和37例鼻咽黏膜柱状上皮细胞中CD147、E-cadherin的表达。结果鼻咽癌细胞和鼻咽黏膜柱状上皮细胞中,CD147阳性表达率分别为74.55%和43.24%,组间差异有统计学意义（P〈0.01）;E-cadherin阳性表达率分别为41.82%和64.86%,组间差异有统计学意义（P〈0.05）。55例鼻咽癌细胞中CD147与E-Cadherin蛋白表达呈负相关（r=-0.269,P〈0.05）。结论鼻咽癌细胞中CD147异常高表达,而E-cadherin表达下降,二者的联合检测对评估鼻咽癌上皮间质转化及预后有重要意义。
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| 关 键 词： | 鼻咽肿瘤 上皮间质转化 CD147 E-钙黏蛋白 |
Significance of CD147 and E-cadherin protein expression in nasopharyngeal carcinoma |
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| LIU Dan,ZHAO Ying-hai,JING Zhi-liang,LUO Ai-hua,JIANG Han-guo,LI Fei-hong.Significance of CD147 and E-cadherin protein expression in nasopharyngeal carcinoma[J].Journal of Guangdong Medical College,2012,30(1):4-6,10. |
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| Authors: | LIU Dan ZHAO Ying-hai JING Zhi-liang LUO Ai-hua JIANG Han-guo LI Fei-hong |
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| Institution: | 1.Department of Pathology,Guangdong Medical College,Zhanjiang 524023,China) |
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| Abstract: | Objective To investigate the significance of CD147 and E-cadherin expression in nasopharyngeal carcinoma（NPC）.Methods Expression of CD147 and E-cadherin in 55 NPCs and 35 columnar epithelia of nasopharyngeal mucosa was detected by SP immunhistochemical method.Results In NPC and nasopharyngeal mucosal columnar epithelia,the positive expression rates of CD147 were 74.55% and 43.24%（P0.01）,and those of E-cadherin were 41.82% and 64.86（P0.05）,respectively.The expression of CD147 and E-cadherin was negatively correlated in NPC（r=-0.269,P0.05）.Conclusion There exist CD147 overexpression and E-cadherin downexpression in NPC.The combined detection of CD147 and E-cadherin can be pivotal in evaluation of epithelial-mesenchymal transformation and prognosis in NPC. |
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| Keywords: | nasopharyngeal neoplasms epithelial-mesenchymal transformation CD147 E-cadherin |
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