| L-肉碱的合成研究 |
| |
| 引用本文： | 李有桂,江娅,薄飞.L-肉碱的合成研究[J].安徽农业大学学报,2012,39(3):441-445. |
| |
| 作者姓名： | 李有桂 江娅 薄飞 |
| |
| 作者单位： | 合肥工业大学化学工程学院,合肥,230009;合肥工业大学化学工程学院,合肥,230009;合肥工业大学化学工程学院,合肥,230009 |
| |
| 基金项目： | 安徽高校省级自然科学研究产学研重点项目(2011AJZR0921)资助 |
| |
| 摘 要： | 以麦芽糖为原料,一步法合成了中间体——(S)-3-羟基-γ-丁内酯,产率为31%;再经开环、手性转化制备了L-肉碱,产率为54%。同时考察了底物、浓度、温度及时间等影响反应的因素。该合成路线避免使用剧毒物质氰化钠、外消旋体的拆分等难题,缩短了反应步骤。
|
| 关 键 词： | 麦芽糖 (S)-3-羟基-γ-丁内酯 L-肉碱 合成 |
| 收稿时间： | 5/5/2011 12:00:00 AM |
Synthesis of L-carnitine |
| |
| LI You-gui,JIANG Ya and BO Fei.Synthesis of L-carnitine[J].Journal of Anhui Agricultural University,2012,39(3):441-445. |
| |
| Authors: | LI You-gui JIANG Ya and BO Fei |
| |
| Institution: | (School of Chemical Engineering,Hefei University of Technology,Hefei 230009) |
| |
| Abstract: | (S)-3-hydroxy-γ-butyrolactone was synthesized from maltose in one step,and the yield was 31%.L-carnitine was then obtained through the ring-opening reaction,a chiral inversion,and the overall yield was 54%.Influential factors upon the reaction such as reaction substrate,concentration,temperature,and time were investi-gated.Difficult problems such as the usage of an extremely poisonous NaCN and the resolution of a racemic modification were avoided,and operational processes were shortened through this synthetic route. |
| |
| Keywords: | maltose (S)-3-hydroxy-γ-butyrolactone L-carnitine synthesis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《安徽农业大学学报》浏览原始摘要信息 |
| 点击此处可从《安徽农业大学学报》下载免费的PDF全文 |
|
