Effects of epidural xylazine on EEG responses to surgical stimulation during isoflurane anaesthesia in dogs |
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Authors: | K A Otto S Piepenbrock B Rischke C Bötel† |
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Institution: | *Abt. Anaesthesiologie II;?Zentrales Tierlaboratorium, Medizinische Hochschule Hannover, Konstanty-Gutschow-Str. 8, D30625 Hannover;**Abt. Unfallchirurgie, Kreiskrankenhaus Pinneberg, Germany |
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Abstract: | The effects of epidural administration of 250 μg/kg xylazine on EEG responses to surgical stimulation of 5 different intensities were evaluated during isoflurane anaesthesia for an experimental orthopaedic procedure in dogs. The dogs were assigned randomly to one of 2 treatment groups receiving either xylazine (n = 4) or equal volumes of sterile water (n = 4) (control group) epidurally. Intense surgical stimulation during removal of a bone graft from the dorsoiliac spine of the ileum was associated with a significantly (P = 0.0339) higher increase in EEG alpha/delta ratio after epidural administration of sterile water than after epidural injection of 250 μg/kg of xylazine. In addition, the preincision baseline values for 80% spectral edge frequency were significantly (P = 0.0339) lower in the xylazine group compared to control dogs. Our results suggest that epidural administration of 250 μg/kg of xylazine during orthopaedic procedures in dogs exerts antinociceptive effects which may be in part mediated by a supraspinal effect of xylazine. |
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