Effects of remifentanil on monophasic action potential and transmural dispersion of repolarization in rabbit myocardium |
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Authors: | LIU Yan-qiu GAO Hong LONG Juan LI Hui ZHANG Kai-qiang |
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Institution: | 1. Faculty of Anesthesiology, Guiyang Medical College, Guiyang 550004, China;
2. Department of Anesthesiology, Affiliated Hospital, Guiyang Medical College, Guiyang 550004, China |
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Abstract: | AIM: To study the effect of remifentanil on monophasic action potential and transmural dispersion of repolarization (TDR) in the 3-layer myocardium of isolated rabbit hearts. METHODS: Adult rabbits (n=18, 2.0 ~ 2.5 kg) were used to isolate the hearts for preparing Langendorff perfusion model. The hearts were randomly divided into 3 groups after perfusion with K-H solution for 15 min: the perfusion in control group (C group) continued for 60 min; the hearts in remifentanil group (R group) were perfused with 12 μg/L remifentanil K-H solution for 60 min; the hearts in remifentanil+aminophylline group (RA group) were given 60-min perfusion of 12 μg/L K-H remifentanil+30 mg/L aminophylline. The HR and 3 layers of myocardial monophasic action potential (MAP) in the left ventricular anterior wall were recorded at time points after balanced infusion for 15 min (T0), and continued perfusion for 15 min (T1), 30 min (T2) and 60 min (T3). The monophasic action potential duration of repolarization at 90% (MAPD90) and the transmural dispersion of repolarization (TDR) were calculated. The early afterdepolarization, delay afterdepolarization and arrhythmia were also observed. RESULTS: In R group, slower HR and prolonger MAPD90 and TDR at T1~T3 were observed as compared with those at T0 (P<0.05). R group showed slower HR and longer MAPD90 and TDR than C group and RA group (P<0.05). CONCLUSION: Remifentanil slows the HR, extends the MAPD90 and increases the TDR, thus being prone to induce reentry. Aminophylline makes HR faster and MAPD90 shorter, thereby reducing the TDR. |
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Keywords: | Remifentanil Monophasic action potential Transmural dispersion of repolarization Electrophysiological techniques cardiac |
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