左炔诺孕酮-炔雌醚对长爪沙鼠的不育效果

采用强制给药的方式测定左炔诺孕酮-炔雌醚复合剂(EP-1)对雌性长爪沙鼠Meriones unguiculatus的不育效果。将试鼠分多剂量、单剂量及对照三组。多剂量组按照10mg/kg剂量,每周给药3天,连续4周;单剂量组按10mg/kg剂量仅给药1次;对照组与多剂量组同时等量以食用油灌胃。4周后与对照组比较,多剂量组子宫、卵巢的形态及其脏器系数、卵巢组织、血清雌二醇(E2)和促黄体生成激素(LH)的含量均有明显变化,且试鼠完全不育;单剂量组未发现子宫、卵巢等性腺的变化,血清E2、LH与对照组的差异不显著,且给药后1个月雌鼠可繁殖正常后代。结果表明,连续给药对雌性长爪沙鼠有生殖抑制作用。

Effect of levonorgestrel-quinestrol on fertility of female Mongolia gerbils, Meriones unguiculats

Effect of levonorgestrel-quinestrol(EP-1)on fertility of female Mongolia gerbils,Meriones unguiculats,was researched.The samples were divided into 3 groups,including the multi-dose treatment groups(at the dose of 10 mg/kg for 3 d each week and for consecutive 4 weeks),single-dose treatment group(at the dose of 10 mg/kg)and CK.After 4 weeks,the ovary and uterus organ coefficient,ovary section,the reproductive hormones(LH and E2)content in the blood serum and the reproduction rate were tested in the laboratory.There are significant differences between the multi-dose treatment groups and the control group;the fertility of the treatment group was completely prohibited,and the reproductive organ as well as the hormone level were significantly reduced.No significant differences of the reproductive organ and the hormone level between single-dose treatment group and the control group,and the fertility of Mongolia gerbils was normal compared with the control group when tested after one month.The results indicated that females of Mongolia gerbils treated with multiple dose of EP-1 are very potential for fertility control of Mongolia gerbils.