RNA干扰技术的应用现状及研究进展

RNA干扰是指外源双链RNA进入细胞以后引起的与其同源mRNA特异性降解的现象,它参与真核生物抵抗病毒侵染,阻断转座子的异常活动,调控基因表达,并广泛存在于生物界。通过介绍RNA干扰技术的发现过程,探讨该技术的作用机理和研究进展,进而提出该技术的未来发展方向。

The Application and the Research Progress of RNA Interference Technique

RNA interference (RNAi) is all evolutionarily conserved eukaryotic adaptive response that leads to the specific degradation of target mRNA species in response to cellular exposure to homologous double-stranded RNA molecules. It is an endogenous pathogenic nucleic acids,and regulates the expression of protein-coding genes.This article deals with the discovery process of RNA interference technique and its action mechanism and research progress and finally points out its developing trend.