氟苯尼考双混悬型乳剂的体外药效学研究

 【目的】为了探明氟苯尼考双混悬型乳剂的体外药效学特征。【方法】以氟苯尼考注射液为对照组对氟苯尼考双混悬型乳剂进行5种细菌的最低抑菌浓度（MIC）、最低杀菌浓度（MBC）和耐药突变选择窗（MSW）的测定，对鼠伤寒沙门氏菌进行抗生素后效应（PAE）和抗生素后亚抑菌浓度效应（PASME）的测定。【结果】相对于普通注射液氟苯尼考双混悬型乳剂对5种细菌的MIC和MBC无明显变化，但其明显缩小了对5种细菌的MSW（P＜0.01），并且明显地延长了对鼠伤寒沙门氏菌PAE和PASME（P＜0.01）。【结论】氟苯尼考双混悬型乳剂在体外能够减小细菌耐药几率，明显延长抗生素对细菌的后效应时间，从而有效地提高抗菌效果。

Studies on Pharmacodynamics in vitro of the Florfenicol Dual Suspension Emulsion

【Objective】 The in vitro pharmacodynamics characteristics of florfenicol dual suspension emulsion (DSEF) were studied in an experiment. 【Method】 The florfenicol injection (FI) was used as the control group and five kinds of bacteria were used for in vitro antibacterial test to determine the minimal inhibitory concentration (MIC), minimal bactericide concentration (MBC) and mutant selection window (MSW), respectively. The S.typhimurium was used for in vitro antibacterial test about post-antibiotic effect (PAE) and post-antibiotic sub-MIC effect (PASME), respectively. 【Result】 Compared with the ordinary injection, the MIC and MBC of DSEF for five kinds of bacteria showed no change obviously. But DSEF narrowed MSW obviously of five kinds of bacteria (P＜0.01) and extended the PAE and PASME significantly of S. typhimurium (P＜0.01). 【Conclusion】DSEF could reduce the bacterial resistance risk and extend the time of its after effect obviously, thereby improved the antibacterial effect.