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不同饲养密度对SPF级BALB/cA裸鼠血生化指标的影响
引用本文:练有文,王晖,倪少凯,欧超伟,李志东,欧阳轶强,钟康银.不同饲养密度对SPF级BALB/cA裸鼠血生化指标的影响[J].湛江医学院学报,2010,28(2):120-122.
作者姓名:练有文  王晖  倪少凯  欧超伟  李志东  欧阳轶强  钟康银
作者单位:练有文,李志东,钟康银,LIAN You-wen,LI Zhi-dong,ZHONG Kang-yin(广东医学院实验动物中心,广东湛江,524023);王晖,WANG Hui(广东药学院);倪少凯,NI Shao-kai(广东医学院预防医学教研室,广东湛江,524023);欧超伟,OU Chao-wei(广东医学院附属医院检验科生化室,广东湛江,524023);欧阳轶强,OUYANG Yi-qiang(广西医科大学) 
摘    要:目的观察不同饲养密度对SPF级BALB/cA裸小鼠血液生化指标的影响。方法取4周龄刚离乳的BALB/cA裸小鼠186只,雌雄各半,分1只/笼的14笼,2只/笼的14笼,4只/笼的8笼,8只/笼的6笼,16只/笼的4笼等5个饲养密度组饲养在M1型小鼠饲养笼至70 d,取血清测定血液生化值并比较结果。结果 4只/笼组的血液生化指标与低密度组(1只/笼、2只/笼)、密度稍大饲养组(8只/笼)相差不大,与高密度饲养组(16只/笼)相差较大。结论饲养密度对实验动物的血液生化指标有影响。

关 键 词:饲养密度  SPF级  BALB/cA裸小鼠  血液生化

Effect of rearing density on biochemical parameters in SPF BALB/cA nude mice
LIAN You-wen,WANG Hui,NI Shao-kai,OU Chao-wei,LI Zhi-dong,OUYANG Yi-qiang,ZHONG Kang-yin.Effect of rearing density on biochemical parameters in SPF BALB/cA nude mice[J].Journal of Guangdong Medical College,2010,28(2):120-122.
Authors:LIAN You-wen  WANG Hui  NI Shao-kai  OU Chao-wei  LI Zhi-dong  OUYANG Yi-qiang  ZHONG Kang-yin
Institution:1.Laboratory Animal Center,Guangdong Medical College,Zhanjiang 524023,China)
Abstract:Objective To observe the influence of rearing density on blood biochemical parameters in SPF BALB/cA nude mice.Methods A total of 186 four-week-old BALB/cA nude mice were randomly divided into 5 groups of different rearing density(1,2,4,8 and 16 mice per cage) and fed in M1 type cages.After 70 days,blood biochemical indices were measured in all groups.Results The biochemical parameters in middle density group(4~8 mice per cage) were similar to those in low density group(1~2 mice per cage),but different from those in high density group(16 mice per cage).Conclusion The rearing density may have some impact on the blood biochemical parameters in laboratory animals.
Keywords:rearing density  SPF  BALB/cA nude mice  blood biochemistry
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