A role for skin gammadelta T cells in wound repair |
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Authors: | Jameson Julie Ugarte Karen Chen Nicole Yachi Pia Fuchs Elaine Boismenu Richard Havran Wendy L |
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Institution: | Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA. |
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Abstract: | Gammadelta T cell receptor-bearing dendritic epidermal T cells (DETCs) found in murine skin recognize antigen expressed by damaged or stressed keratinocytes. Activated DETCs produce keratinocyte growth factors (KGFs) and chemokines, raising the possibility that DETCs play a role in tissue repair. We performed wound healing studies and found defects in keratinocyte proliferation and tissue reepithelialization in the absence of wild-type DETCs. In vitro skin organ culture studies demonstrated that adding DETCs or recombinant KGF restored normal wound healing in gammadelta DETC-deficient skin. We propose that DETCs recognize antigen expressed by injured keratinocytes and produce factors that directly affect wound repair. |
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