Alteration of somatostatin receptor 2 expression in canine mammary gland
tumor |
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Authors: | Kosei SAKAI Tomohiro YONEZAWA Hideyuki YAMAWAKI Toshifumi OYAMADA |
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Institution: | 1)Department of Veterinary Pathology, School of Veterinary Medicine, Kitasato University, Aomori 034–8628, Japan;2)Laboratory of Veterinary Clinical Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113–8657, Japan;3)Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori 034–8628, Japan |
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Abstract: | Somatostatin receptor 2 (SSTR2) is a negative regulator of cell proliferation in human
breast cancer. Since there is little information about SSTR2 in canine mammary gland tumor
(MGT), we clarified its distribution and expression level in normal mammary gland, benign
MGT and malignant MGT. SSTR2 expression determined by immunohistochemical staining was
observed in the cytoplasm of luminal epithelial cells. The intensity was negatively
correlated with malignancy: normal tissues and some of the benign tumors had the highest
levels, while the malignant tumors had little or no SSTR2 expression. As for the Western
blotting, SSTR2 protein level in benign tumors was significantly lower than the normal
mammary gland. On the other hand, SSTR2 protein levels in two of three malignant tumors
were higher than the other groups. These results suggest that SSTR2 expression alters
according to the malignancy of canine MGT. |
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Keywords: | canine malignancy mammary gland tumor somatostatin receptor 2 (SSTR2) |
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