一起群发性奶牛尿素中毒的临床研究

2004年南京某奶牛公寓由于饲养户在奶牛饲料中添加尿素方法不当,引起群发性尿素中毒。该牛群共有奶牛87头,发病64头,药物治疗56头,治愈54头,死亡10头,均为成母牛。作者调查了发病牛群的病史、临床症状、病理变化、治疗情况,对中毒奶牛的血液进行生化分析,并与正常奶牛比较,结果血清谷草转氨酶(AST)、γ-谷氨酰转移酶(GGT)、碱性磷酸酶(ALP)、磷酸肌酸激酶(CK)、磷酸肌酸激酶同工酶(CK-MB)、肌酐(CRE)、尿素氮(UN)、葡萄糖(GLU)、乳酸脱氢酶(LDH-L)等差异极显著(P<0·01),尿素(UREA)、血清K等差异显著(P<0·05),这些指标活性升高说明病牛心肌、胃肠平滑肌、肝肾等存在与病死牛的病理变化相一致的损伤。

Clinical study on ammonia toxicity from urea in dairy cows

Because of misusing urea as cows feed additive in a dairy farm in March 2004, there were 64 cows toxicated, in which 56 were medieated, 54 were cured, 10 died. The history, clinical signs, histopathological changes, treatment and blood biochemistry profile from the poisoning cows were in vestigated. The results showed that AST, GGT, ALP, CK, CK-MB, CRE, UREA, UN, LD in the poisoning cows were significantly different (P<0.05 or P<0.01)from the normal cows, which was coordinated to the pathological changes of lesions of cardiac muscle, stomachs and intestine unstriated muscle, liver, kidney in the dead animals.