| 蛋白质的品质管理 |
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| 引用本文： | 刘泰麟,赵翔,李立新.蛋白质的品质管理[J].安徽农业科学,2012,40(4):1948-1955,2006. |
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| 作者姓名： | 刘泰麟 赵翔 李立新 |
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| 作者单位： | 东北林业大学盐碱地生物资源环境研究中心,东北油田盐碱植被恢复与重建教育部重点实验室,黑龙江哈尔滨150040;东北林业大学盐碱地生物资源环境研究中心,东北油田盐碱植被恢复与重建教育部重点实验室,黑龙江哈尔滨150040;东北林业大学盐碱地生物资源环境研究中心,东北油田盐碱植被恢复与重建教育部重点实验室,黑龙江哈尔滨150040 |
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| 基金项目： | 国家自然科学基金(30840002,30970223);黑龙江省留学归国人员科学基金(LC08C03);中央高校基本科研业务费专项资金(DL09DA02);东北林业大学引进人才科研启动金(015-602042);中国博士后科学基金特别资助(200902365);黑龙江省留学人员科技活动项目择优资助(2009-HLJLix-inLi) |
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| 摘 要： | 概述了蛋白质品质管理中涉及的分子伴侣、激发未折叠蛋白反应(unfolded protein response,UPR)和内质网相关性蛋白质降解途径(ER-associated degradation,ERAD)等的研究进展,并探讨了该领域存在的问题以及发展前景。指出蛋白质的生命过程经历生成、折叠、组装和降解,每个过程都有严格控制。内质网中,各种蛋白质合成、折叠并经修饰形成具有一定构象的功能性蛋白。其在内质网折叠受阻碍时,未折叠的蛋白聚集,激发UPR,使一系列分子伴侣和蛋白质折叠所需修饰酶类表达上调,帮助其完成折叠和装配。如果这些蛋白仍不能正确折叠,则进入ERAD被降解。
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| 关 键 词： | 蛋白质品质管理 未折叠蛋白反应 内质网相关性蛋白质降解 分子伴侣 |
Protein Quality Control |
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| Institution: | LIU Tai-lin et al(Key Laboratory of Saline-alkali Vegetation Ecology Restoration in Oil Field of Ministry of Education,Alkali Soil Natural Environmental Science Center,Northeast Forestry University,Harbin,Heilongjiang 150040) |
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| Abstract: | The paper summarized the research progress in molecular chaperones,unfolded protein response(UPR) and ER-associated degradation(ERAD) involved in the protein quality control,discussed the existing problems and the future development prospect.It was pointed out that the life process of protein experienced four stages of synthesizing,folding,assembling and degradation,each stage required strict quality control.In endoplasmic reticulum(ER),a variety of proteins had been synthesized,folded and undergone modifications to form functional proteins with certain conformation.When the folding was blocked in ER,the unfolded proteins would aggregate and induce the UPR,which up regulated the level of a series of chaperones and modification enzymes to help them to accomplish folding and assembling.If these proteins were still incorrectly folded,they would enter into the ERAD to be degraded. |
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| Keywords: | Protein quality control Unfolded protein response(UPR) ER-associated degradation(ERAD) Molecular chaperones |
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