The effect of maropitant on intraoperative isoflurane requirements and postoperative nausea and vomiting in dogs: a randomized clinical trial |
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| Institution: | 1. Department of Veterinary Medicine, University of Cambridge, Cambridge, UK;2. Department of Veterinary Science, University of Liverpool, Liverpool, UK;3. Royal Navy, Coltman House, Lichfield, UK;1. Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA;2. Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland;1. Anaesthesia Department, Clinical Science and Services, The Royal Veterinary College, Hatfield, UK;2. Soft Tissue Surgery Department, Clinical Science and Services, The Royal Veterinary College, Hatfield, UK;1. Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea;2. The Ian Animal Medical Center, Gangnam-gu, Seoul, Republic of Korea;1. Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Seoul National University, Seoul, South Korea;1. Centro Universitário de Maringá, Maringá, PR, Brazil;2. Department of Anesthesiology, College of Veterinary Medicine, University of Franca, Franca, SP, Brazil;1. Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina;2. Department of Statistics, College of Agriculture and Life Sciences, North Carolina State University, Raleigh, North Carolina |
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| Abstract: | ObjectiveTo establish if preoperative maropitant significantly reduced intraoperative isoflurane requirements and reduced clinical signs associated with postoperative nausea and vomiting (PONV) in dogs.Study designRandomized clinical trial.AnimalsTwenty-four healthy, client-owned dogs undergoing routine ovariohysterectomy.MethodsPremedication involved acepromazine (0.03 mg kg?1) combined with methadone (0.3 mg kg?1) intramuscularly 45 minutes before anaesthetic induction with intravenous (IV) propofol, dosed to effect. Meloxicam (0.2 mg kg?1) was administered intravenously. Dogs were randomly assigned to administration of saline (group S; 0.1 mL kg?1, n = 12) or maropitant (group M; 1 mg kg?1, n = 12) subcutaneously at time of premedication. Methadone (0.1 mg kg?1 IV) was repeated 4 hours later. Anaesthesia was maintained with isoflurane in oxygen, dosed to effect by an observer unaware of group allocation. The dogs were assessed hourly, starting 1 hour postoperatively, using the short form of the Glasgow Composite Pain Score (GCPS), and for ptyalism and signs attributable to PONV score from 0 (none) to 3 (severe)] by blinded observers. Owners completed a questionnaire at the postoperative recheck.ResultsOverall mean ± standard deviation end-tidal isoflurane percentage was lower in group M (1.19 ± 0.26%) than group S (1.44 ± 0.23%) (p = 0.022), but was not significantly different between groups at specific noxious events (skin incision, ovarian pedicle clamp application, cervical clamp application, wound closure). Cardiorespiratory variables and postoperative GCPS were not significantly different between groups. Overall, 50% of dogs displayed signs attributable to PONV, with no difference in PONV scores between groups (p = 0.198). No difference in anaesthetic recovery was noted by owners between groups.ConclusionsMaropitant reduced overall intraoperative isoflurane requirements but did not affect the incidence of PONV.Clinical relevanceMaropitant provided no significant benefits to dogs undergoing ovariohysterectomy with this anaesthetic and analgesic protocol, although clinically significant reductions in isoflurane requirements were noted. |
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| Keywords: | Maropitant Ovariohysterectomy Nausea Vomiting MAC Isoflurane |
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