Central inhibitory activity of the aqueous extract of Crinum giganteum |
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Authors: | Amos S Binda L Akah P Wambebe C Gamaniel K |
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Institution: | Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Idu Industrial Area P.M.B. 21, Garki, Abuja, FCT, Nigeria. samsonamos@yahoo.co.uk |
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Abstract: | The aqueous extract of Crinum giganteum given intraperitoneally at doses of 6.25, 12.5 and 25 mg/kg in rats prolonged the duration of pentobarbital sleeping time and in mice reduced spontaneous motor activity, decreased the exploratory activity and attenuated amphetamine-induced stereotype behavior. The intraperitoneal and oral preliminary LD(50) in mice were found to be 627 and 1468 mg/kg, respectively. The data obtained suggest that the aqueous extract of C. giganteum contains some biologically active principles with sedative activity. |
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