| 转座子沉默与DNA甲基化 |
| |
| 引用本文： | 鲁亚萍,周明兵.转座子沉默与DNA甲基化[J].浙江农林大学学报,2021,38(3):634-643. |
| |
| 作者姓名： | 鲁亚萍 周明兵 |
| |
| 作者单位： | 浙江农林大学 省部共建亚热带森林培育国家重点实验室，浙江 杭州 311300 |
| |
| 基金项目： | 浙江自然科学基金重点资助项目(LZ19C160001)；国家自然科学基金资助项目(31870656，31470615) |
| |
| 摘 要： | 转座子(transposable elements，TEs)在生物体基因组可以通过转座或逆转座移动，它拷贝数的大规模增加是基因组不稳定的重要因素，因此，维持TEs沉默是宿主进化的方向。DNA甲基化被认为是沉默TEs的可遗传表观遗传修饰方式，同时也在维持基因组稳定、基因印迹、调节基因表达中发挥作用。本研究综述了TEs对生物基因组进化和基因表达的影响，重点总结了以DNA甲基化为主的转座子沉默机制的最新研究进展，归纳了环境因素通过DNA去甲基化调控转座子跳跃的机理。图4参82
|
| 关 键 词： | 植物学 转座子 转座子沉默 DNA甲基化 胁迫 |
| 收稿时间： | 2020-05-22 |
On transposon silencing and DNA methylation |
| |
| LU Yaping,ZHOU Mingbing.On transposon silencing and DNA methylation[J].Journal of Zhejiang A&F University,2021,38(3):634-643. |
| |
| Authors: | LU Yaping ZHOU Mingbing |
| |
| Institution: | State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou 311300, Zhejiang, China |
| |
| Abstract: | Transposable elements (TEs) can be moved by means of transposition or reverse transposition in the genome of an organism, whose copy number in large numbers is an important factor for genome instability. Therefore, it is the direction of host evolution to maintain TEs silence. DNA methylation, generally considered to be a heritable epigenetic modification method for silencing TEs, plays a role in the maintainance of genome stability, genetic imprinting and the regulation of gene expression. This study is aimed at an overview of the impact of TEs on the evolution of biological genome and gene expression, a summary of the latest research progress of transposon silencing mechanism dominated by DNA methylation, and an investigation of the mechanism of environmental factors that regulate transposon jumping via DNA demethylation. Ch, 4 fig. 82 ref.] |
| |
| Keywords: | |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《浙江农林大学学报》浏览原始摘要信息 |
| 点击此处可从《浙江农林大学学报》下载免费的PDF全文 |
|
