Comment on "Large-scale sequence analysis of avian influenza isolates" |
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| Authors: | Holmes Edward C Lipman David J Zamarin Dmitriy Yewdell Jonathan W |
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| Affiliation: | Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, Mueller Laboratory, University Park, PA 16802, USA. |
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| Abstract: | Obenauer et al. (Research Articles, 17 March 2006, p. 1576) reported that the influenza A virus PB1-F2 gene is evolving under strong positive selection, as documented by an extremely high ratio of the number of nonsynonymous nucleotide substitutions to the number of synonymous substitutions (dN/dS). However, we show that this observation is likely to be an artifact related to the location of PB1-F2 in the +1 reading frame of the PB1 gene. |
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