Curative-intent radiation therapy as a treatment modality for appendicular and axial osteosarcoma: a preliminary retrospective evaluation of 14 dogs with the disease |
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| Authors: | C. U. Walter W. S. Dernell S. M. LaRue S. E. Lana M. H. Lafferty T. A. LaDue S. J. Withrow |
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| Affiliation: | Animal Cancer Center, Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA; Animal Cancer Center, Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA; Florida Veterinary Specialists, Busch Lake Boulevard, Tampa, FL, USA |
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| Abstract: | Canine osteosarcoma is a common bone malignancy associated with aggressive local disease and rapid metastasis. Current local therapeutic modalities do not provide curative‐intent options for dogs with significant orthopaedic or neurologic disease, dogs which are denied amputation or dogs with non‐resectable lesions. The goals of this retrospective study included the evaluation of local control, survival, and time to the development of metastases in 14 dogs treated with curative‐intent radiation therapy and chemotherapy. Median local disease control was 202 days (79–777). Median survival was 209 days (79–781). Median time to metastasis was 314 days (7–645). No significant correlation was found between the outcome and pre‐treatment alkaline phosphatase levels, radiographic appearance, tumour site, radiation dose or chemotherapeutics administered. In these dogs, full‐course radiation therapy in conjunction with chemotherapy was not found to yield equivalent results to the standard of care options. |
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| Keywords: | appendicular axial canine limb sparing osteosarcoma radiation therapy |
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