Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in
mouse perinatal development |
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| Authors: | Risa YABUSAKI Hidetomo IWANO Sumito TSUSHIMA Nanako KOIKE Naoko OHTANI Kentaro TANEMURA Hiroki INOUE Hiroshi YOKOTA |
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| Institution: | 1) Laboratory of Veterinary Biochemistry, Graduate School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi Ebetsu, Hokkaido 069–8501, Japan;2) Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University, 1–1 Amamiya-machi, Tsutsumidori, Aoba-ku, Sendai, Miyagi 981–8555, Japan |
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| Abstract: | Bisphenol A (BPA) is a widely used industrial chemical that disrupts endocrine function.
BPA is an endocrine disrupting chemical (EDC) that has been demonstrated to affect
reproductive organ development, brain development, metabolic disease and post-natal
behavior. Accordingly, Bisphenol analogs, Bisphenol F (BPF, bis (4-hydroxyphenyl) methane)
and Bisphenol AF (BPAF, 4,4-hexafluoroisopropylidene) diphenol) are used as replacements
for BPA. BPA is mainly metabolized by UDP-glucuronosyltransferase (UGT), UGT2B1, but this
effective metabolizing system is weak in the fetus. In the present study, we demonstrated
that hepatic UGT activity toward BPAF was very weak, in comparison with BPA and BPF, in
the fetus, pups and dams. Conversely, hepatic UGT activity toward BPF was very weak in the
fetus and newborn pups, and was increased to the same level as BPA post-partum. In
conclusion, BPAF possibly tends to accumulate in the fetus, because of weak metabolism
during the perinatal period, suggesting that the metabolism of individual Bisphenol
analogs requires assessment to properly gauge their risks. |
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| Keywords: | Bisphenol A Bisphenol AF Bisphenol F UDP glucuronosyl transferase (UGT) |
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