Treatment of Mycotic Rhinitis With Itraconazole in Three Horses |
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| Authors: | Nancy L Korenek Alfred M Legendre Frank M Andrews James T Blackford Paul Y Wan Michael A Breider Michael G Rinaldi |
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| Institution: | Department of Rural Practice, College of Veterinary Medicine, University of Tennessee, Knoxville;Department of Urban Practice, College of Veterinary Medicine, University of Tennessee, Knoxville;Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville;Department of Pathology, University of Texas Health Science Center and Laboratory Service, Audie L. Murphy Memorial Veterans, San Antonio, TX |
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| Abstract: | Itraconazole, a third-generation azole, was evaluated for treatment of resistant nasal mycotic infections in horses. Two horses with Aspergillus spp nasal granulomas and 1 horse with Conidiobolus coronatus nasal infection were treated with itraconazole (3 mg/kg PO bid). One of the horses with nasal aspergillosis was also treated by surgical resection of the nasal septum. The treatment time for the horses ranged from 3 to 4.5 months. No adverse effects were noted in any of the horses during the treatment period. Peak and trough serum itraconazole concentrations were < 0.5 μg/mL in all 3 horses. Itraconazole (3 mg/kg PO bid) appears to be effective in the treatment of nasal Aspergillus spp infections in horses because the fungal infection was eliminated in both horses. One horse still had excessive nasal sounds during exercise and was retired from training, whereas the other horse returned to normal. The nasal C. coronatus infection appeared resistant to itraconazole treatment in the affected horse because the granulomas were still present after 4.5 months of treatment. |
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