慢呼宁口服液对人工感染鸡慢性呼吸道病的治疗试验研究

为验证慢呼宁口服液对鸡慢性呼吸道病的治疗效果,将21日龄三黄肉鸡按常规方法随机分为6组,每组30只,分别为:慢呼宁口服液高、中(相当于推荐剂量)、低剂量组及镇喘散对照组、感染对照(感染不给药)组、健康对照组,除健康对照组外其余各组鸡均进行鸡毒支原体的人工感染。各药物治疗组连续给药7 d,停药后继续观察14 d,分别对其临床疗效、平均增重与病理变化等进行观察与评价。结果显示慢呼宁口服液高、中剂量组对感染鸡有明显的疗效,能明显降低血清抗体反应阳性率,气囊损伤减少率达90%以上,试验鸡的鸡毒支原体抗体阳性检出率为10%、20%,平均增重分别为596.1和661.3 g。而镇喘散对照组在气囊损伤减少率(82.5%)和平均增重方面较慢呼宁口服液中、高剂量组小,而鸡毒支原体抗体阳性检出率(30%)则较高。结果表明,慢呼宁口服液对鸡慢性呼吸道病有较好的防制效果,其作用优于镇喘散。

Research on Manhuning Oral Liquid to Treat the Chicken Infected Artificially with Chronic Respiratory Disease

In order to verify the effect of Manhuning oral liquid on treating chronic respiratory disease in chickens,the 21-day-old Yellow broiler chickens were randomly divided into six groups (n=30) including high-dose group,middle-dose (equivalent to the recommended dose) group,low-dose group of Manhuning oral liquid and Zhenchuan power group,model group,the control group. The chickens in each group were artificially infected with Mycoplasma gallisepticum except to the control group. The chickens in each administration group were given the drug continuously for 7 days and then all of the chickens were observed for 14 d. The clinical efficacy,average weight gain and pathological changes were observed and evaluated,respectively. The results showed that the high-dose and middle-dose group of Manhuning oral liquid had an apparent effect on infected chickens and the serum Mycoplasma antibody-positive rate could be apparently reduced,while the rate of airbag injury reduction could be both above 90% and the positive rates of chickens' Mycoplasma antibody were 10% and 20%. Also the average weight gains were 596.1 and 661.3 g. In Zhenchuan power group,the rate of airbag injury reduction (82.5%) and the average weight gain were lower than the high-dose group and middle-dose group of Manhuning oral liquid,while the serum Mycoplasma antibody-positive rate (30%) was higher. The results showed that Manhuning oral liquid had good effect on prevention of the chronic respiratory disease in chicken,and its effect was better than the Zhenchuan power.