艰难梭菌毒素致病机理的研究进展

艰难梭菌是一种革兰氏阳性厌氧芽胞梭菌,是人类肠道感染的主要致病菌,其主要致病因素为毒素A(肠毒素)和毒素B(细胞毒素).毒素A引发细胞损伤后,毒素B即可侵入肠黏膜,引起细胞病变,导致一系列与感染相关的临床表现.同时,艰难梭菌毒素也是引起猪、鸡等畜禽发生腹泻的重要因素,因此探讨艰难梭菌毒素对机体的损伤作用,有利于揭示艰难梭菌的致病机理,为其防控提供理论依据.

Research Progress on the Pathogenesis of Clostridium difficile Toxins

Clostridium difficile is a G⁺ anaerobic and one of the most important pathogenic bacteria in human intestinal infection. Its major pathogenic factors are toxin A (enterotoxin) and toxin B (cytotoxin).After the cell damage caused by toxin A, toxin B can invade the intestinal mucosa, cause cell lesion, lead to cytopathy and a series of clinical manifestations in infection.Meanwhile, Clostridium difficile toxin is also an important factor causing diarrhea in pigs, chickens and other livestock. Exploring the damage of Clostridium difficile toxin to the body is helpful to reveal the pathogenesis of Clostridium difficile, which provides a theoretical basis for prevention and control of Clostridium difficile.