Research Progress on Cytochrome P450 2E1 |
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| Authors: | WU Shu-qin WANG Cheng-shuang WANG Xin LI Peng |
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| Affiliation: | Heilongjiang Bayi Agricultural University, Daqing 163319, China |
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| Abstract: | Cytochrome P450 2E1 (CYP2E1) is one of the body's metabolite of drugs and low molecular weight compounds mainly enzymes, and the increasing of activity or expression of CYP2E1 is closely related with the clinical variety of diseases. This paper reviews the research progress of protein structure, function, positioning mechanism and other aspects of genetic polymorphisms of CYP2E1 at home and abroad. Thereby the paper could lay the foundation for further exploration of the biological effects of CYP2E1 and its relationship with clinical disease. |
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| Keywords: | cytochrome P450 2E1 (CYP2E1) protein structure function gene polymorphism liver toxicity |
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