Polyhydroxylated Steroids from the South China Sea Soft Coral Sarcophyton sp. and Their Cytotoxic and Antiviral Activities |
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| Authors: | Kai-Kai Gong Xu-Li Tang Gang Zhang Can-Ling Cheng Xing-Wang Zhang Ping-Lin Li Guo-Qiang Li |
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| Affiliation: | 1.Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Yushan Road 5, Qingdao 266003, China; E-Mails: (K.-K.G.); (G.Z.); (C.-L.C.); (X.-W.Z.);2.College of Chemistry and Chemical Engineering, Ocean University of China, Songling Road 238, Qingdao 266100, China; E-Mail: |
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| Abstract: | Chemical investigation on the soft coral Sarcophyton sp. collected from the South China Sea yielded three new polyhydroxylated steroids, compounds (1–3), together with seven known ones (4–10). Their structures were established by extensive spectroscopic methods and comparison of their data with those of the related known compounds. All the isolates possessed the 3β,5α,6β-trihydroxylated steroidal nucleus. The cytotoxicities against selected HL-60, HeLa and K562 tumor cell lines and anti-H1N1 (Influenza A virus (IAV)) activities for the isolates were evaluated. Compounds 2, 3 and 5–8 exhibited potent activities against K562 cell lines with IC50 values ranging from 6.4 to 10.3 μM. Compounds 1, 6–8 potently inhibited the growth of HL-60 tumor cell lines, and 6 also showed cytotoxicity towards HeLa cell lines. In addition, preliminary structure-activity relationships for the isolates are discussed. The OAc group at C-11 is proposed to be an important pharmacophore for their cytotoxicities in the 3β,5α,6β-triol steroids. Compounds 4 and 9 exhibited significant anti-H1N1 IAV activity with IC50 values of 19.6 and 36.7 μg/mL, respectively. |
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| Keywords: | soft coral Sarcophyton sp. polyhydroxylated steroids cytotoxicities anti-H1N1 activity |
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