Anti-histone antibodies in dogs with leishmaniasis and glomerulonephritis |
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| Institution: | 1. Michigan State University College of Human Medicine, Grand Rapids, Michigan;2. Spectrum Health Hospital System, Grand Rapids, Michigan;3. Glickman Urological & Kidney Institute, Cleveland Clinic, Cleveland, Ohio;1. School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China;2. School of Science, Harbin University of Science and Technology, Harbin 150080, China;1. Department of Computing, Federal Institute of Ceará, Maracanaú, Brazil;2. Department of Computing, Federal University of Ceará, Fortaleza, Brazil;1. Research Group on Natural Computing, Department of Computer Science and Artificial Intelligence, Universidad de Sevilla, Avda. Reina Mercedes s/n, 41012, Sevilla, Spain;2. Key Laboratory of Image Information Processing and Intelligent Control of Education Ministry of China, School of Automation, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, China;3. School of Electric and Information Engineering, Zhengzhou University of Light Industry, Zhengzhou 450002, China;1. Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Japan;2. Food Safety Commission, Cabinet Office, Government of Japan, Japan;3. Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Japan;1. College of Water Resources and Architectural Engineering, Northwest A&F University, Yangling 712100, China;2. Research School of Engineering, The Australian National University, ACT 2601, Australia |
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| Abstract: | The association between serum anti-histone antibodies and glomerulonephritis was studied in 43 dogs with leishmaniasis (Leishmania infantum). Dogs with increased serum creatinine levels and urine protein-creatinine ratio >1 were considered to have glomerulonephritis. Moderately elevated anti-histone antibodies were found in 38.89% (7/18) of infected dogs without glomerulonephritis, whereas 88% of dogs with glomerulonephritis (22/25) showed moderate or strongly elevated anti-histone antibodies. Prevalence of positive anti-histone antibodies reactions and mean serum concentration was significantly higher (P < 0.001; P < 0.0001) in infected dogs with glomerulonephritis. Correlation between anti-histone antibodies and urine protein-creatinine ratio was significant when groups were analysed together (P < 0.046). Positive predictive value for glomerulonephritis of positive anti-histone antibodies was 88%. In conclusion, high anti-histone antibodies are significantly associated with glomerulonephritis. Although other factors must be involved, dogs with moderate or strong positive anti-histone antibodies reactions may have a higher probability to develop glomerular lesions in canine leishmaniasis. |
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