基于肝毒性探讨何首乌临床合理应用

目的 促进临床合理使用何首乌，降低肝毒性不良反应发生率。方法 通过查阅文献及相关实验数据分析，探索何首乌肝毒性发生的潜在因素，并针对因素提出临床合理使用建议和用药监护。结果 何首乌肝毒性的发生与炮制方法、炮制程度、化学成分、特异体质等因素有关，临床使用时应注重药品质量，辨证用药，对易感人群加强监护。结论 合理使用何首乌，可降低肝毒性不良反应发生率。

Reasonable Clinical Application of Polygoni Multiflori Radix Based on Hepatotoxicity

Objective To promote rational use of Polygoni Multiflori Radix (Heshouwu) in clinic, to reduce the incidence rate of adverse effects of hepatotoxicity. Methods The potential factors of hepatotoxicity in polygonum multiflorum thunb through consulting document and analysing related experimental data were explored, and then the reasonable clinical use suggestion and the medication guardianship according to the factors were put forward. Results The occurence of hepatotoxicity of Polygoni Multiflori Radix were related to these factors, such as processing method, processing degree, chemical constituents, idiosyncrasy. The quality of drugs, dialectical medication and intensive care for susceptical people should be paid more attention. Conclusion Rational use of Polygoni Multiflori Radix could reduce the incidence rate of hepatotoxicity adverse reactions.