| 旋毛虫致小鼠心肌损伤的试验 |
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| 引用本文： | 赵风强,韩彩霞,路义鑫,徐佳,张子群,谢晓峰,宋铭忻. 旋毛虫致小鼠心肌损伤的试验[J]. 中国兽医杂志, 2012, 48(2): 27-30,97 |
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| 作者姓名： | 赵风强 韩彩霞 路义鑫 徐佳 张子群 谢晓峰 宋铭忻 |
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| 作者单位： | 1. 东北农业大学动物医学学院,黑龙江哈尔滨,150030
2. 黑龙江出入境检验检疫局,黑龙江哈尔滨,150036 |
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| 基金项目： | “十一五”国家科技支撑计划重大项目(2010-BAD04B01);兰州家畜疫病病原生物学国家重点实验室开放课题(SKLVEB2009KFKT005);黑龙江省普通高等学校青年学术骨干支持计划项目(1153G007) |
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| 摘 要： | 本研究旨在对重度感染旋毛虫后小鼠心肌损伤的研究。通过对小鼠接种旋毛虫,1 000条/只,分别于不同时间对血清中心肌损伤标志物H-FABP、CK-MB和cTnT进行动态检测,以及心肌组织病理形态学变化进行观察。结果显示,H-FABP比CK-MB、cTnT敏感性高(P<0.05),出现及达到高峰的时间最早;感染旋毛虫后19d～24d,心肌组织损伤最为严重。H-FABP可用于早期旋毛虫病患者心肌损伤的诊断,具有较高的敏感性和特异性。
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| 关 键 词： | 旋毛虫 心肌损伤 H-FABP |
Research on myocardial injury in mice infected with Trichinella spiralis |
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| ZHAO Feng-qiang , HAN Cai-xia , LU Yi-xin , XU Jia , ZHANG Zi-qun , XIE Xiao-feng , SONG Ming-xin. Research on myocardial injury in mice infected with Trichinella spiralis[J]. Chinese Journal of Veterinary Medicine, 2012, 48(2): 27-30,97 |
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| Authors: | ZHAO Feng-qiang HAN Cai-xia LU Yi-xin XU Jia ZHANG Zi-qun XIE Xiao-feng SONG Ming-xin |
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| Affiliation: | 1(1.College of Veterinary Medicine,Northeast Agricultural University,Harbin 150030,China; 2.Heilongjiang Entry-Exit Inspection and Quarantine Bureau,Harbin 150036,China) |
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| Abstract: | This experiment was conducted to study myocardial injury in mice infected with Trichinella spiralis.Each mouse was infected with 1000 of Trichinella spiralis and H-FABP,CK-MB and cTnT were detected in serum and myocardial tissue pathological histological changes were observed.The results showed that H-FABP had higher sensitivity than CK-MB,cTnT(P<0.05),occurred and reached the peak value,after 19~24 d infected with Trichinella spiralis,the most serious injury in myocardial tissue was noted.H-FABP could be used for early high sensitivity and specificity diagnosis of myocardial injury in trichinellosis. |
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| Keywords: | Trichinella spiralis myocardial injury H-FABP |
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