| 松蘑提取液对D-半乳糖致衰老小鼠抗氧化作用的研究 |
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| 引用本文： | 栾海云,王桂华,许勇,杨茗. 松蘑提取液对D-半乳糖致衰老小鼠抗氧化作用的研究[J]. 安徽农业科学, 2012, 40(15): 8471-8472 |
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| 作者姓名： | 栾海云 王桂华 许勇 杨茗 |
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| 作者单位： | 滨州医学院药学院药物研究所,山东烟台,264003;滨州医学院药学院药物研究所,山东烟台,264003;滨州医学院药学院药物研究所,山东烟台,264003;滨州医学院药学院药物研究所,山东烟台,264003 |
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| 摘 要： | [目的]研究松蘑提取液对D-半乳糖所致衰老小鼠的抗氧化作用。[方法]将50只小鼠随机分成空白对照组、模型组和松蘑提取液低、中、高剂量组,采用D-半乳糖复制衰老模型,试验6周后处死动物,测定血清、脑及肝脏中的超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性及丙二醛(MDA)的含量。[结果]松蘑提取液可明显提高衰老小鼠血清、脑及肝脏中的SOD和GSH-Px的活性,降低MDA的含量,且呈剂量依赖性。[结论]松蘑提取液有一定的抗衰老作用,其机制可能与抗氧化作用有关。
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| 关 键 词： | 松蘑(Tricholoma matsutake) D-半乳糖 抗氧化 |
Antioxidant Effects of Tricholoma matsutake Extracting Solution on Aging Mice Induced by D-galactose |
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| Affiliation: | LUAN Hai-yun et al(Binzhou Medical University,Yantai,Shandong 264003) |
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| Abstract: | [Objective] To study the antioxidant effects of Tricholoma matsutake extracting solution on aging mice induced by D-galactose.[Method] 50 mice were randomly divided into blank control group,model group,low-dose group,middle-dose group,and high-dose group.Aging mice were induced by D-galactose and they were killed after six weeks.The SOD activity,GSH-Px activity and MDA content in mice serum,bran and liver were detected.[Result] T.matsutake extracting solution could significantly enhance the SOD activity and GSH-Px activity in mice serum,bran and liver,and reduce the MDA content.And there was dose-dependent effects.[Conclusion] T.matsutake extracting solution had certain anti-aging effects,and the mechanism might had certain relationship with the antioxidation. |
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| Keywords: | Tricholoma matsutake D-galactose Anti-oxidation |
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