小鼠镉的蓄积性毒性试验研究

选用SPF级昆明种小鼠140只，做急性毒性和蓄积性毒性试验。通过急性毒性试验，得出Cd LD50为94.1 mg/kg体重。蓄积性毒性试验中，试验组小鼠每日灌胃染毒1次，Ⅰ组，1/10 LD50（Cd 9.41 mg/kg体重）；Ⅱ组，1/5 LD50（Cd 18.82 mg/kg体重）；Ⅲ组，1/3 LD50（Cd 31.36 mg/kg体重）；对照组Cd为 0 mg/kg体重，试验期4周。结果显示，染镉组小鼠生长发育落后于对照组（P<0.05或P<0.01），组织镉残留量高于对照组（P<0.05或P<0.01），肝细胞和肾小管上皮细胞变性，脾脏瘀血，并有明显的剂量—效应关系。

Studies on Accumulative Toxicity of Cadmium in Experimental Mice

140 KM mice were made experimental Cd poision.LD50 of a Cd was 94.1 mg/kg body weight by acute toxicity test. There were four groups in accumulative toxicity experiment, Ⅰ group, 1/10 LD50（Cd 9.41 mg/kg）, Ⅱ group, 1/5 LD50（Cd 18.82 mg/kg）, Ⅲ group,1/3 LD50（Cd 31.36 mg/kg） and the control group（Cd 0 mg/kg）for 4 weeks. The results showed that body weight in dose groups were much lower than in control group（P<0.05 or P<0.01）.Compared with the control group, the sediment of cadmium in liver, kidney, heart, meat and bone were significant among these groups, especially the sediment of cadmium in liver and kidney. Histopathologicall，the hepatocytes and renaltubular epithelium were degenerate and the spleen gored in dose groups.