| 内毒素对山羊肝脏的病理损伤和654-2的保护效应 |
| |
| 引用本文： | 高洪,张双玲,赵汝,唐兆新,陈万芳.内毒素对山羊肝脏的病理损伤和654-2的保护效应[J].黑龙江畜牧兽医,2000(4):4-6. |
| |
| 作者姓名： | 高洪 张双玲 赵汝 唐兆新 陈万芳 |
| |
| 作者单位： | [1]云南农业大学动物科技学院,云南昆明 [2]南京农业大学动物医学院,云南昆明 |
| |
| 基金项目： | 云南省应用基础研究项目，国家自然科学基金，，，， |
| |
| 摘 要： | 通过给山羊静注大肠杆菌内毒素（ＥＴ）诱导ＥＴ休克，探讨ＥＴ休克时山羊肝脏的病理损伤，并观察山莨菪碱（６５４－２）对其影响。结果表明，ＥＴ自理组在注射后５ｈ，肝脏表现出明显的病理变化，特征为实质细胞退行性变化，微血管淤血、有透明血栓形成，血管内有淋巴细胞和中性粒细胞粘聚，且肝脏有明显的超微结构变化。６５４－２能有效地缓解或减轻ＥＴ引起的毒性损伤。
|
| 关 键 词： | 内毒素 山莨菪碱 病理损伤 肝脏 山羊 保护效应 |
| 文章编号： | 1004-7034(2000)04-0004-03 |
| 修稿时间： | 1999年8月30日 |
Protectiue Effects of Anisodamine on Endotoxin-induced Liver Lesions in Goats |
| |
| GAO Hong,ZHANG Shuang-ling,ZHAO Ru,TANG Zhao-xin,CHEN Wan-fang.Protectiue Effects of Anisodamine on Endotoxin-induced Liver Lesions in Goats[J].Heilongjiang Animal Science And veterinary Medicine,2000(4):4-6. |
| |
| Authors: | GAO Hong ZHANG Shuang-ling ZHAO Ru TANG Zhao-xin CHEN Wan-fang |
| |
| Abstract: | Changes of endotoxin-induced liver lesions and effects of anisodamine were studied after intravenous injection of E.Coli endotoxin(1800 EU/kg body weight) and anisodamine(2.5 mg/kg body weight )alone as well as in combination.In 5 hours after endotoxin treatment,some Prominent Pathological Changes,including typical histopathological and ultrastructural lesions occurred in the liver.At the end of the experiment,however,in endotoxin and anisodamine wexposure group,above-mentioned lesions were mild.It followed that anisodamine can simultaneously antagonize the toxicity of endotoxin in goats. |
| |
| Keywords: | endotoxin anisodamine Pathological lesions liver goat |
| 本文献已被 CNKI 维普 等数据库收录！ |
