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Invoices and farmer interviews for vaccine-exposure measurement in turkey-broiler production
Authors:Chauvin C  Bouvarel I  Beloeil P-A  Sanders P  Guillemot D
Institution:

aAFSSA, French Agency for Food Safety, Pig and Poultry Veterinary Research Laboratory, Epidemiology and Quality Assurance Research Unit, Zoopôle, BP 53, 22440 Ploufragan, France

bITAVI, Technical Institute for Poultry Farming, Station de Recherches Avicoles, BP 1, 37380 Nouzilly, France

cAFSSA, French Agency for Food Safety, Laboratory for the research and study of veterinary medicinal products and disinfectants, La Haute Marche Javené, 35302 Fougeres, France.

dInstitut Pasteur, Resource Center for Biostatistics, Epidemiology and Pharmacoepidemiology applied to Infectious Diseases, 25-28 rue du Dr Roux, 75015 Paris, France

Abstract:Exposure measurement in pharmaco-epidemiological studies can be based on various sources that do not always concur. However, reliability is an important criterion when selecting the method used to assess exposure and interpreting the results obtained. An analysis based on invoices might be more informative and more accurate to assess vaccines exposure (yes/no) in turkey broiler production than a questionnaire administered to farmers, which is nevertheless more feasible and less time-consuming. We compared the two methods to assess vaccination exposure in 239 turkey broiler flocks reared in 129 farms in 2000–2001. The agreement (crude agreement and kappa) was calculated, and association between discrepancy and farm and flock characteristics was investigated.

Marek's-disease vaccine, Newcastle-disease vaccine, turkey haemorrhagic-enteritis vaccine and turkey-rhinotracheitis vaccine exposures were reported on the questionnaire for 2.1, 27.6, 93.0, and 98.3% of flocks, respectively, and for 2.1, 29.3, 89.4, and 86.6%, of invoices for the flocks studied, respectively. A discrepancy was observed in 24.9% of flocks. A discrepancy was observed more frequently in specialised farms without any other animal production (OR = 3.6; CI = 1.5, 8.9) and when the farmer did not know whether vaccination had been performed in the hatchery (OR = 7.1; CI = 2.6, 19.7).

Keywords:Drug-exposure measurement  Pharmaco-epidemiology  Reliability  Turkey broilers  Vaccines
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