柔嫩艾美球虫常州株对5种抗球虫药的抗药性分析

将柔嫩艾美耳球虫(E.tenella)常州分离株感染14日龄苏禽黄羽肉鸡，设立5个用药组、1个感染不用药对照组和1个不感染不用药对照组，以相对卵囊产量、病变记分减少率、最适抗球虫百分数和抗球虫指数为指标对该虫株对球虫宁、地克珠利、马杜霉素、磺胺氯吡嗪、癸氧喹酯5种常用抗球虫药的抗药性进行了综合评定，分析了该地区球虫的抗药性及用药对策。结果表明，该虫株对癸氧喹酯敏感，对球虫宁、地克珠利、马杜霉素、磺胺氯吡嗪具有完全抗药性，提示目前常州地区球虫抗药性非常严重，癸氧喹酯抗球虫疗效最好，其他药物应合理使用、应慎用、减少或暂停使用。

Resistance to Five Anticoccidial Drugs of Eimeria tenella Isolated from Changzhou Area

One Eimeria tenella isolated from Changzhou district of Jiangsu province was studied in a battery test for evaluating drug resistance against five commonly used anticoccidial drugs including sulfamethoxydiazine and diaveridine permix, sulfachloropyrazine sodium, toltrazuril, maduramycin and decoquinate. Suqin yellow chickens were randomly divided into seven groups of 10 each, which contained five medicated groups, one uninfected and unmedicated control, and one unmedicated and infected control. Chickens of medicated groups and infected control were prophylactic medicated and infected with sporulated oocysts at the age of 14 days. Drug resistance was assessed for each drug by calculating the relative oocyst production (ROP), reduction of lesion scores (RLS), percentage optimum anticoccidial activity (POAA) and anticoccidial index (ACI) . Results revealed that the E. tenella isolated from Changzhou district were sensitive to decoquinate, complete resistant to other four drugs. It suggested that in Changzhou district E. tenella was seriously resistant to drugs, decoquinate can be uesd, and the other drugs should be used reasonably or not be used at present.